Notes on Act V, scene iii
Yond's: yonder (over there) is
Duchess' grave: this stage direction is in the first Quarto, indicating that the Duchess provides the voice for the echo.
make scrutiny: examine closely
asleep: he means this literally, not as a metaphor for death. If he knew of their deaths, Antonio surely would not want to make peace with the brothers.
ague: trembling associated with a fever, but in this case because of fear
second: support you in this endeavor
blood: family, his nephew
however: however things turn out
sufferings: we can rise above the suffering that fortune sends, if we so choose, or we can merely complain about them.
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